分析,准备和工业规模逆流色谱分离的建模
Artak E Kostanyan1, Andrey A Voshkin1
1Kurnakov Institute of General & Inorganic Chemistry, Russian Academy of Sciences, Leninsky a Prospekt 31, Moscow 119991, Russia.
Journal of chromatography. A
|December 2, 2023
概括
对逆流色谱 (CCC) 分离的数学建模至关重要. 这项研究比较了精确和近似的模拟,找到适合小规模分析和准备CCC的近似模型,而工业规模需要精确的细胞模型方程.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 分离科学 分离科学
- 染色体学 染色体学 是一种染色学.
背景情况:
- 反流色谱 (CCC) 过程在规模上有很大的不同,从分析到工业应用.
- 有效的分离依赖于适当的设备设计和操作参数.
- 数学建模对于优化CCC过程设计和操作至关重要.
研究的目的:
- 为了比较两种不同的数学建模方法在不同尺度上的CCC分离的准确性.
- 评估近似高斯分布模型与准确的平衡细胞模型之间的适用性.
- 根据CCC运营的规模,为选择合适的建模策略提供指导.
主要方法:
- 开发并提出了用于模拟各种规模的CCC分离的方程.
- 利用精确的平衡细胞模型和简化的高斯分布模型进行模拟.
- 在不同的条件下比较两种模型的模拟结果,包括加载的溶液体积和平衡细胞的数量.
主要成果:
- 准确和近似模拟之间的差异随着较大的加载溶液体积和较少的平衡细胞而增加.
- 大致模型适用于模拟分析和准备性CCC,采用小样本体积.
- 工业规模的CCC需要精确的细胞模型方程,特别是在使用大量的混合器-定位器级联时.
结论:
- 对于CCC模拟的数学模型的选择取决于操作的规模.
- 大致的高斯模型对于小规模,低体积的CCC应用非常有效.
- 精确的细胞模型模拟对于优化大规模,大量的工业CCC流程是不可或缺的.
相关概念视频
01:15Optimizing Chromatographic Separations
411
Optimizing chromatographic separations is crucial for obtaining clean separations in a minimum amount of time. Optimization is required for several factors, including kinetic effects related to band broadening, plate height, capacity factor, and separation factor.
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
411
01:10Chromatography: Introduction
4.4K
Chromatography is a technique used to separate compounds based on differences of partitioning between two phases, the stationary phase and the mobile phase.
The phase in which the compounds linger or on which the compounds adsorb is called the stationary phase, whereas the mobile phase is the solvent that carries the solutes to be analyzed. In traditional column chromatography, the mixture flows through the stationary phase, and the compounds partition between the stationary and mobile phases...
The phase in which the compounds linger or on which the compounds adsorb is called the stationary phase, whereas the mobile phase is the solvent that carries the solutes to be analyzed. In traditional column chromatography, the mixture flows through the stationary phase, and the compounds partition between the stationary and mobile phases...
4.4K
01:11High-Performance Liquid Chromatography: Introduction
2.1K
High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:
In HPLC, two phases play a critical role in the separation process:
2.1K
01:13Principles Of Column Chromatography
6.8K
The chromatography technique was first invented in 1901 by Michael S. Tswett, a Russian botanist, to separate plant pigments using organic solvents. Further, in 1941, Archer John Porter Martin and R. L. M. Synge modified the technique by packing silica gel into a column. A mixture of amino acids was then separated on the packed column using chloroform and water mixture as the mobile phase. This was the first report on column chromatography. At present, column chromatography is a widely used...
6.8K
00:57High-Performance Liquid Chromatography: Instrumentation
1.9K
High-performance liquid chromatography, or HPLC, is an analytical technique that separates liquid samples under high pressures. An HPLC instrument consists of glass bottles for storing solvents called mobile phase reservoirs. HPLC-grade solvents are used to maintain high purity, and the dissolved gases are removed using a degasser, such as a vacuum pumping system or sparging with helium. The solvents are then pumped into the analytical column using a screw-driven syringe or reciprocating pumps.
1.9K
01:12Chromatographic Methods: Classification
2.3K
Chromatographic techniques are classified in three ways: the classification is based on the physical state of the stationary and mobile phases, how the mobile phase and the stationary phase contact each other, or through the chemical or physical processes that isolate the components of the sample. Typically, the mobile phase is either a liquid or gas, while the stationary phase is either a solid or a liquid layer applied to a solid surface.
Chromatographic techniques are typically named by...
Chromatographic techniques are typically named by...
2.3K