血液恶性瘤患者的心血管风险:系统性审查和元分析
Jung Hahn Yong1, Aaron Shengting Mai1, Andrija Matetić2
1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
The American journal of cardiology
|December 2, 2023
概括
患有血液性恶性瘤的患者面临更高的心脏病发作,心力衰竭和中风的风险. 这一系统性审查强调了迫切需要加强心血管保健在这个人群.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
- 在瘤学瘤学.
背景情况:
- 患有血液性恶性瘤 (HMs) 的患者在未来心血管 (CV) 事件的风险增加.
- 了解与HMs相关的特定CV风险对于主动的患者管理至关重要.
研究的目的:
- 系统地审查和分析现有文献,以量化HMS患者未来心血管事件的风险.
- 为了比较急性心肌梗塞 (AMI),心力衰竭 (HF) 和中风在HMs患者与对照人群中的发病率.
主要方法:
- 在Medline和EMBASE数据库中进行了全面的搜索,截至2023年1月31日.
- 包括的研究比较了HM患者和没有HM患者的CV结果.
- 危险比率 (HRs) 和95%置信区间 (CI) 为AMI,HF和中风计算.
主要成果:
- 分析包括了15项研究,涉及超过190万个人 (178,602名HM).
- 与对照组相比,HM患者的AMI (HR1.65),HF (HR4.82) 和中风 (HR1.60) 风险显著增加 (所有p <0.001).
- 敏感性分析表明,非霍奇金淋巴瘤患者中风风险较高 (HR 1.31,p=0.03).
结论:
- 血液性恶性瘤与急性心肌梗塞,心力衰竭和中风的风险大幅增加有关.
- 这些发现强调了为诊断为血液性恶性瘤的患者优先考虑心血管护理的必要性.
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