用febuxostat装载的奇多纳米载体的制造和优化,以获得更好的药理动力学特征
Muhammad Tayyab1, Muhammad Tahir Haseeb2, Tariq G Alsahli3
1College of Pharmacy, University of Sargodha, Sargodha 40100, Pakistan; Department of Pharmacy, Quaid-i-Azam University, Islamabad 44000, Pakistan.
International journal of biological macromolecules
|December 2, 2023
概括
这项研究开发了奇托桑纳米颗粒,以改善疏水性药物的口服输送. 这种新的纳米粒子药物递送系统显著提高了药物的生物可用性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 疏水性药物通常由于溶解性和吸收性较低,因此口服生物可用性较差.
- 纳米颗粒药物递送系统 (DDS) 为克服这些局限性提供了一个有希望的策略.
研究的目的:
- 开发和优化含有febuxostat的奇多纳米颗粒 (FLC NPs),以提高口服生物可用性.
- 调查开发的FLCNP的物理化学特性和药物释放特征.
主要方法:
- 使用修改的离子凝方法制备FLCNP.
- 采用中央复合设计来优化反应条件和评估可变相互作用.
- 特性包括颗粒大小,泽塔潜力,PDI,捕获效率,FTIR,PXRD,TGA,TEM,SEM和AFM.
主要成果:
- 优化的FLCNP (配方Q) 显示颗粒大小为234.7nm,PDI为0.158,泽塔电位为25.8mV,捕获效率为76.9%.
- 材料表征证实了成分的兼容性和统一,密集的纳米粒子结构.
- 在体外和体外研究表明,药物释放持续,相对生物可用性增加了286.63%.
结论:
- 素纳米颗粒有效地提高了像febuxostat这样的疏水药物的捕获效率和口服生物可用性.
- 开发的FLC NP配方提供了可行的DDS,用于提高难溶性药物的治疗疗效.
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