终身乳制品消费和乳腺癌风险:根据瘤亚型进行前性队列研究
Emily Riseberg1, You Wu2, Wai Ching Lam3
1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
The American journal of clinical nutrition
|December 2, 2023
概括
总体而言,乳制品摄入量与乳腺癌风险无关. 然而,奶酪消费与风险降低有关,而青少年的牛奶摄入量略有增加. 根据乳制品类型,生命阶段和瘤亚型,发现结果各不相同.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 关于乳制品和乳腺癌风险存在不一致的发现.
- 饮食评估的时间可能会影响观察到的关系.
研究的目的:
- 调查乳制品消费与乳腺癌发病率之间的关系.
- 通过更年期状态和瘤分子亚型来分析这些关联.
主要方法:
- 从1980年到2018年,前性队列研究 (护士健康研究) 与63,847名女性参与者进行了跟踪.
- 通过经过验证的食物频率调查问卷和青少年回忆评估的饮食摄入量.
- 用于估计风险的多变量考克斯比例危险模型.
主要成果:
- 总体乳制品或牛奶摄入量与乳腺癌风险之间没有显著的关联.
- 青少年牛奶摄入量与乳腺癌风险之间的积极关联 (HR:1.09).
- 较高的寿命和绝经前奶酪摄入量与适度较低的乳腺癌风险相关 (HRs:分别为0.90和0.89).
- 对于绝经前的牛奶摄入量和乳腺癌观察到异质性,对于雌激素受体阳性 (HR:0.84) 和雌激素受体阴性 (HR:1.36) 亚型有不同的关联.
结论:
- 总体而言,乳制品消费与乳腺癌风险无关.
- 关联因乳制品类型,消费的生命阶段和瘤分子亚型而异.
- 需要进一步的研究来澄清特定的乳制品成分及其对乳腺癌亚型的差异性影响.
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