怀孕期间的咖啡因摄入量和不良结果:综合性审查
Ricardo Rohweder1, Thanyse de Oliveira Schmalfuss2, Diessy Dos Santos Borniger3
1Sistema Nacional de Informação sobre Agentes Teratogênicos (SIAT), Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Reproductive toxicology (Elmsford, N.Y.)
|December 2, 2023
概括
怀孕期间的咖啡因消费可能会损害胎儿的发育,增加流产,低出生体重和发育问题的风险. 即使在每天低于200毫克的剂量中,也会显示出相关的关联,因此需要进一步研究安全摄入水平.
科学领域:
- 产科和妇科 产科和妇科
- 周围生理学 周围生理学
- 发育毒理学 发展毒理学
背景情况:
- 怀孕期间咖啡因消费很普遍.
- 咖啡因穿过胎盘,对胚胎和胎儿发育构成潜在风险.
- 现有的关于咖啡因在怀孕期间影响的研究产生了相互矛盾的结果,没有关于安全剂量的共识.
研究的目的:
- 进行对研究的综合性审查,检查怀孕期间咖啡因摄入的结果.
- 综合有关母亲咖啡因消费与不良妊娠结果之间的联系的证据.
- 为了确定咖啡因对胎儿发育的潜在剂量依赖影响.
主要方法:
- 从六个数据库中综合审查研究.
- 广泛的医学主题标题 (MeSH) 术语用于全面的文献搜索.
- 包括英语和葡萄牙语的文章,没有日期限制.
- 选了16192篇最初的文章,在严格的评估后最终包括了59篇.
主要成果:
- 发现咖啡因摄入量与妊娠流产风险增加,低出生体重,心脏和生殖器异常,体重增加以及神经发育/神经行为结果之间的关联.
- 观察到的效应经常是剂量依赖的.
- 没有证明与早产有显著的关联,尽管一项研究表明,高剂量的咖啡因会略微减少妊娠年龄.
结论:
- 在怀孕期间确定安全的咖啡因摄入水平是具有挑战性的,因为研究异质性和难以准确量化消费.
- 即使咖啡因摄入量低于每天推的200毫克,也与不良结果有关.
- 为了确定怀孕期间低剂量摄入的安全性,进一步进行精心设计的研究,精确量化咖啡因摄入量至关重要.
更多相关视频
相关概念视频
Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Factors Affecting Drug Response: Overview
2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K
Pharmacovigilance
850
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
850
Insufficient Sleep and Sleep Deprivation
147
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
147
Substance Use Disorders Affecting Sleep
170
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
170
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K


