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通过双向门德尔随机化分析,探索肠道微生物群对腹腔大动脉瘤风险的影响

Xiaoqin Zhou¹, Weiqiang Ruan², Ting Wang³

¹Department of Vascular Surgery, West China Hospital, Sichuan University, Chengdu, PR China; Research Center of Clinical Epidemiology and Evidence-Based Medicine, West China Hospital, Sichuan University, Chengdu, PR China; Center of Biostatistics, Design, Measurement and Evaluation (CBDME), Department of Clinical Research Management, West China Hospital, Sichuan University, Chengdu, PR China.

Journal of vascular surgery

|December 2, 2023

概括

这项研究揭示了肠道微生物和腹腔大动脉瘤 (AAA) 风险之间的双向联系. 一些肠道细菌会增加AAA风险,而其他细菌会降低AAA风险,提供新的治疗点.

科学领域:

遗传学遗传学是一个
微生物学微生物学
心血管疾病心血管疾病

背景情况:

腹腔大动脉瘤 (AAA) 与肠道微生物群的变化有关,但因果关系尚不清楚.
了解这种肠-大脑轴相互作用对于AAA病原体的洞察至关重要.

研究的目的:

调查肠道微生物种群与腹腔大动脉瘤 (AAA) 风险之间的因果关系.
探索AAA和肠道微生物群组成之间的双向影响.

主要方法:

进行了一种双向的双样本孟德尔随机化分析.
利用了来自18,340名肠道微生物群和353,087名AAA个体的全基因组关联研究数据.
分析了196种肠道微生物种类,以确定它们对AAA风险的因果影响,反之亦然.

主要成果:

九种微生物种群对AAA风险有因果影响.
增加的AAA风险与Bilophila,Catenibacterium,家族XIII AD3011组,Oxalobacter和Prevotella 7属有关.
降低AAA风险与Lentisphaeria类,Victivallales序列,Victivallaceae家族和Anaerotruncus属有关.
AAA影响了14种微生物种类,其中Lentisphaeria和Victivallales的双向关联被注意到.

结论:

新证据支持肠道微生物群和AAA风险之间的相互因果关系.
这些发现为AAA病原体提供了新的见解.
结果表明,对AAA的微生物组为基础的治疗策略有潜力.

关键词:

腹腔大动脉动脉瘤腹腔大动脉动脉瘤因果关系是因果关系.全基因组关联研究研究.我们的肠道微生物群.门德尔的随机化

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