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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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相关实验视频

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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击中目标:通过随机对照试验为质子束疗法开发高质量的证据.

E M Hudson1, F Slevin2, K Biscombe3

  • 1Leeds Cancer Research UK Clinical Trials Unit, Leeds Institute of Clinical Trials Research, University of Leeds, Leeds, UK.

Clinical oncology (Royal College of Radiologists (Great Britain))
|December 2, 2023
PubMed
概括
此摘要是机器生成的。

英国有三项临床试验将质子束疗法 (PBT) 与传统放射疗法进行比较,以评估其有效性并减少长期副作用. 患者报告的结果和生活质量是本次PBT研究的关键评估.

关键词:
临床试验的设计质子束疗法是一种质子束疗法.辐射疗法 辐射疗法随机对照试验是随机对照试验.研究网络研究网络.

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科学领域:

  • 辐射瘤学 辐射瘤学
  • 临床试验 临床试验
  • 医学物理 医学物理

背景情况:

  • 英国国家卫生服务的质子束疗法 (PBT) 战略为高质量证据生成提供了机会.
  • 随机对照试验 (RCT) 对于评估新的癌症治疗方法,如PBT,至关重要.

研究的目的:

  • 总结英国正在进行的三项多中心第三阶段PBT实验室试验 (TORPEDO,PARABLE,APROACH).
  • 详细介绍未来PBT试验开发的关键设计特征和结果评估.
  • 解决关于PBT临床益处的不确定性,重点关注毒性降低和患者报告的结果.

主要方法:

  • 在三种不同的癌症类型中比较PBT与光子辐射疗法:口腔状细胞癌,乳腺癌和小胞质瘤.
  • 多学科团队设计,涉及临床医生,试验人员,科学家,患者倡导者和国际合作者.
  • 包括翻译研究组件来研究毒性机制.

主要成果:

  • 这三个RCT (TORPEDO, PARABLE, APPROACH) 正在积极招募和比较PBT与传统放射治疗.
  • 在研究中始终关注减少长期放射治疗相关毒性.
  • 评估患者报告的结果和与健康有关的生活质量是评估PBT益处的核心.

结论:

  • 英国正在通过这些RCT建立一个具有国际意义的PBT研究组合.
  • 将RCT数据与国家PBT结果注册表结合起来,将为未来的研究创造一个有价值的资源.
  • 这种全面的方法将促进后续PBT试验的设计和交付.