其他原因的死亡率,根据部分与其他原因的死亡率. 彻底切除术:年龄和阶段分析
Andrea Baudo1, Reha-Baris Incesu2, Simone Morra3
1Division of Urology, Cancer Prognostics and Health Outcomes Unit, University of Montréal Health Center, Montréal, Québec, Canada; Department of Urology, IRCCS Policlinico San Donato, Milan, Italy.
Clinical genitourinary cancer
|December 2, 2023
概括
部分切除术可以降低所有年龄段的早期 (T1a) 癌患者的其他原因死亡率. 然而,对于更晚期 (T1b,T2) 细胞癌,没有观察到这种生存益处.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 腎臟病學 (nephrology) 是一種醫學專業.
- 在瘤学瘤学.
背景情况:
- 细胞癌 (RCC) 是一种常见的恶性瘤.
- 手术管理的选择包括部分瘤切除术 (PN) 和彻底瘤切除术 (RN).
- 外科手术对非癌症特异性死亡率的影响是患者结局的一个重要考虑因素.
研究的目的:
- 为了比较局部细胞癌 (T1a,T1b,T2阶段) 患者的部分切除术和激进切除术之间的其他原因死亡率.
- 分析不同患者年龄组的这些结果.
主要方法:
- 对监测,流行病学和最终结果 (SEER) 数据库 (2010-2020) 的回顾性分析.
- 包括局部RCC (T1a-T2,N0,M0) 和2-10厘米之间的瘤大小的患者,他们接受了PN或RN.
- 使用累积发病率图表和多变量竞争风险回归模型.
主要成果:
- 在68,195名患者中,42%患有PN,58%患有RN.
- 在T1a RCC患者中,5年其他原因死亡率为PN的6%,RN的11%.
- 在所有年龄段的T1a患者中,PN独立预测了较低的其他原因死亡率 (HR:0.73,P <.001),包括小组≤59,60-69和≥70岁.
- 在T1b (8%与10%相比) 或T2 (8%与9%) RCC患者中没有观察到PN与RN相比的其他原因死亡率优势.
结论:
- 部分切除术与所有年龄段的T1a细胞癌患者因其他原因死亡率的降低有关.
- 部分切除术对T1b或T2细胞癌的其他原因死亡率没有临床意义的好处,无论患者的年龄如何.
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