从中年到晚年,代谢不健康和健康肥胖之间的转换
Peggy Ler1, Elsa Ojalehto1, Yiqiang Zhan2
1Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177, Stockholm, Sweden.
International journal of obesity (2005)
|December 2, 2023
概括
随着时间的推移,代谢健康的肥胖症可以转变为代谢综合征,但许多个人在整个生命中保持或恢复不同体重指数类别的代谢健康.
科学领域:
- 老年学是指老年学的学科.
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 代谢健康的肥胖通常被认为是短暂的,长期数据有限,特别是在晚年.
- 了解整个生命周期中代谢健康的转变对于公共健康至关重要.
研究的目的:
- 通过身体质量指数 (BMI) 类别,研究代谢健康和不健康状态之间的长期转换.
- 通过双胞胎研究来检查这些从中年到晚年的人生过渡.
主要方法:
- 代谢健康被定义为缺乏代谢综合征 (MetS).
- 在三个年龄组 (50-64,65-79,≥80) 的个体子集中可视化表型转换.
- 根据786名瑞典双胞胎的BMI类别对代谢健康状况的转换模型使用Cox回归,随访时间长达27年.
主要成果:
- 代谢综合征和超重/肥胖的患病率随着年龄的增长而增加.
- 在所有年龄组中,五分之一的个体保持了代谢健康的超重或肥胖.
- 在代谢健康的个体中,59%的人患有MetS;转化在肥胖中更频繁 (56%的风险高于正常体重).
- 在患有MetS的个体中,60%的人恢复了代谢健康,无论BMI类别如何.
结论:
- 代谢健康状况是动态的,转换发生在所有BMI类别的两个方向.
- 虽然肥胖会增加患METS的风险,但随着时间的推移,许多人可以保持或恢复新陈代谢健康.
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