在患有多系统炎症综合征的儿童中,骨髓衍生抑制细胞和T细胞群
Katherine E Bline1,2, Anna L Wilt3, Robin N Alexander4
1Center for Vaccines and Immunity, Nationwide Children's Hospital, Columbus, OH, USA. Katherine.Bline@nationwidechildrens.org.
Pediatric research
|December 2, 2023
概括
患有多系统炎症综合征 (MIS-C) 的儿童表现出肌髓衍生抑制细胞 (MDSC) 的增加和T细胞的减少. 在MIS-C中MDSC扩张与本研究的临床结果没有相关性.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 关键护理医学 关键护理医学
背景情况:
- 儿童多系统炎症综合征 (MIS-C) 是SARS-CoV-2感染后的高度炎症状况,可能导致多器官功能障碍和死亡.
- 已知骨髓衍生抑制细胞 (MDSC) 在炎症状态下扩大并抑制T细胞功能.
- 在MIS-C的病理生理学中MDSC的作用及其与T细胞淋巴衰竭的关联需要进一步研究.
研究的目的:
- 在被诊断患有MIS-C.的儿童中检查骨髓原抑制细胞 (MDSC) 的水平.
- 确定MDSC扩张与MIS-C患者T细胞淋巴衰竭之间的关联.
- 探索MDSC水平与MIS-C.重症儿童临床结果之间的相关性.
主要方法:
- 进行了一项前性观察性研究.
- 在入院后48小时内,从22名患有MIS-C的儿童和21名年龄匹配的健康对照人群中采集了血液样本.
- 流细胞计被用来识别和量化MDSC,T细胞和自然杀手 (NK) 细胞种群.
主要成果:
- 与健康对照组相比,患有MIS-C的儿童的MDSC水平显著更高.
- 在MIS-C患者的重症监护室 (ICU) 组中,MDSC扩张持续了超过三周.
- 在ICU中的重症MIS-C患者显示T细胞和NK细胞的绝对数量明显较低.
结论:
- 患有MIS-C的重症儿童表现出MDSC的扩张,伴随着T细胞和NK细胞数量的减少.
- 该研究没有发现MDSC水平和临床结果 (如心脏功能障碍,住院时间或需要血管活性支持) 之间的显著关联.
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