阿托瓦斯塔丁改善了唾液转化和胸部X射线严重性得分
O O Adewole1, B A Omotoso2, M Ogunsina3
1Department of Medicine, Obafemi Awolowo University, Ile Ife, Department of Medicine, Obafemi Awolowo University Teaching Hospitals Ile Ife.
这项研究发现,阿托瓦斯塔丁,当添加到标准抗结核病 (TB) 药物时,是安全的,并改善治疗结果. 接受阿托瓦斯塔丁治疗的患者在治疗结核病方面显示出更好的微生物学和放射学结果.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 研究阿托瓦斯塔丁与标准抗结核病 (TB) 药物结合的安全性和有效性.
- 专注于以前没有接受过治疗的无并发性肺结核患者.
研究的目的:
- 为了评估添加阿托瓦斯塔丁到标准结核病治疗的安全性和有效性.
- 评估结核病患者的微生物学和放射学结果.
主要方法:
- 第二阶段B,多中心,开放标签,随机化研究.
- 150名参与者被分配到标准护理或标准护理加阿托瓦斯塔丁 (每天40毫克2个月).
- 主要终点:安全性 (严重不良事件) 和有效性 (阴性唾液培养);次要终点:胸部X射线 (CXR) 严重性得分.
主要成果:
- 不良事件的严重程度在两组之间是可比的;肌肉疼痛在阿托瓦斯塔丁组更频繁 (16%vs5%).
- 在阿托瓦斯塔丁组中,培养负率更高 (97%对85.1%,P=0.02).
- 在阿托瓦斯塔丁组中,CXR严重性得分的较大降低 (37%对22%).
结论:
- 阿托瓦斯塔丁是一种安全的结核病辅助疗法.
- 阿托瓦斯塔丁在结核病患者中显示出改善的微生物学和放射学结果.
- 支持使用阿托瓦斯塔丁来增强标准抗结核病药物治疗方案.
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