皮肤T细胞淋巴瘤与牛皮的风险 生物疗法
Mitchell S Davis1, Riley K Spencer1,2, Chandler E Johnson1,3
1Department of Dermatology, University of California San Francisco, Floor 04, Room N426, 2340 Sutter Street, Box 0808, San Francisco, CA, 94115, USA.
Dermatology and therapy
|December 3, 2023
概括
皮肤T细胞淋巴瘤 (CTCL) 在使用牛皮生物制剂的患者中罕见. 大多数报告的CTCL病例都涉及瘤坏死因子 (TNF) 抑制剂,没有任何与IL-23抑制剂相关.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 牛皮生物药物与皮肤T细胞淋巴瘤 (CTCL) 风险之间的关联需要进一步描述.
- 牛皮的治疗方法,包括生物药物,需要持续监测潜在的不良事件的安全性,如CTCL.
研究的目的:
- 通过临床试验和登记册,通过临床试验和登记册确定接受生物治疗的牛皮患者中CTCL的发生率.
- 系统地审查报告的CTCL病例,这些病例发生在曾经用过生物药治疗牛皮的患者中.
主要方法:
- 在clinicaltrials.gov搜索FDA批准的牛皮生物学试验的第三期和第四期试验.
- 进行了 Medline 搜索牛皮登记册,以评估 CTCL 发病率.
- 进行了与生物疗法相关的CTCL病例的系统文献审查.
主要成果:
- 在临床试验 (3期35,801名受试者中有2例) 和注册 (34,111名受试者中有1例) 中,CTCL发病率非常低.
- 瘤坏死因子 (TNF) 抑制剂与报告的CTCL病例数量最多 (34) 相关,其次是IL-17 (7) 和IL-12/23 (6) 抑制剂.
- 没有报告与IL-23抑制剂使用相关的CTCL病例.
结论:
- 在使用生物药物治疗牛皮的患者中,CTCL的发展似乎很罕见.
- 虽然CTCL不常见,但大多数报告的病例涉及TNF抑制剂;IL-23抑制剂没有显示相关的CTCL病例.
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