在成功移植肝脏之前和之后的脂质乱
Damian Gojowy1, Joanna Urbaniec-Stompór1, Joanna Adamusik1
1Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.
Acta biochimica Polonica
|December 3, 2023
概括
肝移植 (LTx) 后,脂质障碍如高甘油三血症和高胆固醇血症显著增加. 这些心血管风险因素的流行可能与肝脏疾病的初始原因有关.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 移植医学 移植医学
背景情况:
- 肝移植 (LTx) 是对末期肝病的重要治疗方法.
- 心血管并发症可能会影响LTx后的结果.
- 脂质疾病是需要评估的关键心血管风险因素.
研究的目的:
- 评估肝移植前后脂质疾病的发生率.
- 在LTx患者中识别脂质疾病作为心血管风险因素.
- 分析脂质疾病与肝病病因学的关系.
主要方法:
- 对111名LTx后至少2年生存的患者进行了回顾性分析.
- 在LTx.之前和两年后评估失脂症患病率.
- 分析与肝病原因相关 (酒精,病毒,自身免疫).
主要成果:
- 在LTx (P<0.001) 后,高甘油三血症 (13.5%至40.5%) 和高胆固醇血症 (17.1%至51.4%) 显著增加 (P<0.001).
- 过高甘油三血症和高胆固醇血症的年均发病率分别为16.2%和20.7%.
- 与自身免疫性原因相比,酒精性肝病的失脂症患病率更高.
结论:
- 在肝移植后,失脂症的患病率显著增加.
- 移植前的肝病的病因可能会影响移植后的脂质失调率.
- 在LTx后,监测和管理脂质疾病至关重要.
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