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Updated: Jul 9, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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改变多功能金属沙佩龙中的相对金属结合亲和力,以对突变的p53重新激活

Kalvin Kwan1, Omar Castro-Sandoval1, Benjamin Ma1

  • 1Department of Chemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

Journal of inorganic biochemistry
|December 3, 2023
PubMed
概括

研究人员开发了新的小分子,通过提供Zn2+来稳定突变的p53蛋白. 这种方法旨在恢复野生类型的功能并减少与癌症相关的p53功能障碍,提供了一种新的治疗策略.

关键词:
细胞毒性 细胞毒性连接体设计 连接体设计金属的章节之一.这就是ROSOS ROS.在p53蛋白质中,p53蛋白质是

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