低级系统性炎症与老年人的特定领域认知表现和认知衰退有关:来自TUDA研究的数据
Adam H Dyer1, Helene McNulty2, Aoife Caffrey2
1Department of Age-Related Healthcare, Tallaght University Hospital, United Kingdom; Department of Medical Gerontology, School of Medicine, Trinity College Dublin, United Kingdom.
Neurobiology of aging
|December 3, 2023
概括
慢性炎症标志物,包括介素-6 (IL-6) 和瘤缩因子-α (TNF-α),与老年人的认知能力下降有关. 这些细胞因子的较高水平和它们的比率预测认知表现较差,特别是在女性中.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 老年学是一门学科.
背景情况:
- 关于慢性炎症与衰老中的认知功能之间的联系存在相互矛盾的发现.
- 血清细胞因子,如IL-6,IL-10和TNF-α,是关键的炎症标记物.
- 认知能力下降是人口老龄化的一个重大问题.
研究的目的:
- 研究血清细胞因子与老年人认知表现之间的横截面和纵向关联.
- 检查特定细胞因子 (IL-6,IL-10,TNF-α) 和通过RBANS测量的认知领域之间的关系.
- 探索性别,年龄和APOE基因型的潜在修饰效应.
主要方法:
- 一大批认知健康的老年人 (n=3270) 进行了横截面评估.
- 测量了血清细胞因子水平 (IL-6,IL-10,TNF-α).
- 认知功能使用可重复电池评估神经心理状态 (RBANS) 进行评估.
- 一个子组 (n=725) 经历了长度评估,平均时间为5.4年.
主要成果:
- 较高的IL-6,TNF-α和IL-6:IL-10比率与较差的全球认知表现 (RBANS) 交叉相关.
- TNF-α与视觉空间和注意力领域的缺陷的关联最强.
- 从长度上看,较高的IL-6:IL-10比率预测了整体认知,即时记忆和视觉空间性能受损.
- 这些关联在女性中更为明显.
结论:
- 血清IL-6和TNF-α水平升高与老年人认知功能受损有关.
- IL-6:IL-10比率是认知能力下降的重要预测因素,特别是在女性中.
- 炎症可能在认知衰老中起着至关重要的作用,具有潜在的性别特异性影响.
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