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Updated: Jul 9, 2025

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甲基转移酶Set7/9控制PARP1的表达,并调节乳腺癌细胞对西斯的反应

Dmitry Myadelets1, Sergey Parfenyev1, Julia Vasileva1

  • 1Institute of Cytology, Russian Academy of Sciences, 194064, St Petersburg, Russian Federation.

Biochemical and biophysical research communications
|December 3, 2023
PubMed
概括

Set7/9蛋白在乳腺癌中至关重要,它影响DNA修复和对西斯普拉丁的耐药性. 降低Set7/9使PARP1稳定,导致耐药性,但在Set7/9缺乏细胞中,将西斯与尼拉帕里布结合克服了这一问题.

关键词:
乳腺癌 乳腺癌 乳腺癌西斯普拉丁 (Cisplatin) 是一种尼拉巴里布尼拉巴里布PARP1 的第一部分在SETD7中,SETD7是SETD7.设置7/9 甲基转移酶

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