细胞衰老在儿科垂体瘤中的影响
Jose Mario Gonzalez-Meljem1, Juan Pedro Martinez-Barbera2
1Tecnologico de Monterrey, School of Engineering and Sciences, Mexico City, Mexico.
EBioMedicine
|December 3, 2023
概括
细胞衰老,一旦被认为是被动的,积极驱动癌症和垂体瘤. 准衰老细胞为这些疾病提供了潜在的新疗法.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 内分泌学 在内分泌学.
背景情况:
- 细胞衰老是一种不可逆转的细胞循环停止状态.
- 衰老细胞在历史上被认为是被动的,但现在被认为是疾病的积极参与者,包括癌症.
- 衰老程序就像一把双刃剑,最初防止瘤生长,但也通过分泌的因素促进炎症和瘤的进展.
研究的目的:
- 审查癌症衰老细胞的分子特征和生物功能.
- 讨论细胞衰老在 pituitary 瘤中的作用,特别是 adamantinomatous craniopharyngioma (ACP) 和 pituitary 腺瘤.
- 探索针对 pituitary 瘤中衰老细胞的治疗潜力.
主要方法:
- 在癌症中细胞衰老的文献综述.
- 关于垂体腺瘤和ACP衰老的证据分析.
- 讨论关于诱导或向衰老的研究.
主要成果:
- 衰老细胞在癌症中起着双重作用,作为防御机制和促进瘤生长的促进者.
- 在垂体腺瘤中,衰老被认为是预防瘤的机制.
- 在阿达曼蒂诺马图斯瘤 (ACP) 中,衰老细胞在动物模型和人类瘤中促进瘤的发展.
结论:
- 细胞衰老是 pituitary 瘤发展的关键因素,在不同类型的瘤中具有不同的作用.
- 衰老细胞促进了ACP的生长,与它们在垂体腺瘤中所扮演的抑制瘤作用形成鲜明对比.
- 向衰老细胞是对 pituitary 瘤的一种有前途的治疗策略.
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