不同的骨肌肉质量指数,身体功能和炎症之间的关联在肥胖的弱小的老年人中
Li Feng Tan1, Yiong Huak Chan2, A Denishkrshna3
1Healthy Ageing Programme, Alexandra Hospital, National University Health System, Singapore.
Archives of gerontology and geriatrics
|December 3, 2023
概括
该研究发现,尾骨肌肉质量指数超过BMI (ASMIbmi) 与肥胖老年人的更好的身体功能和更低的炎症有关. 尾骨肌肉质量指数超过身体脂肪百分比 (ASM) 也与BMI组的手握强度相关.
科学领域:
- 老年学是一门学科.
- 肥胖问题研究研究
- 肌肉生理学 肌肉生理学
背景情况:
- 在肥胖老年人肌肉质量和质量的最佳测量方面缺乏共识.
- 肥胖和衰老与身体衰退和慢性炎症的风险增加有关.
- 预先脆弱的肥胖老年人代表了一个需要特定评估工具的弱势群体.
研究的目的:
- 评估四种不同的肌肉质量指数与身体功能和炎症的关联,在疲软前肥胖的老年人中.
- 确定最相关的肌肉质量指数,以评估这一群体的健康结果.
主要方法:
- 一项涉及407名社区居住的弱势前老年人的横截面研究.
- 收集的数据包括人口统计,认知,身体功能 (步行速度,握力,SPPB),身体组成和炎症生物标志物.
- 参与者被分为三个身体质量指数 (BMI) 三级进行分析.
主要成果:
- 在最高的BMI三位数 (T3) 中,尾骨肌肉质量指数超过BMI (ASMIbmi) 显示与EQ-5D指数,手握强度 (HGS),短物理性能电池 (SPPB) 评分和介质素-6 (IL-6) 水平有显著的关联.
- 尾骨肌肉质量指数与体重 (ASMIwt) 与EQ-5D指数相关,尾骨肌肉质量指数与身体脂肪百分比 (ASMbfp) 与HGS相关.
- 高血压与所有肌肉质量指数在中BMI三位数 (T2) 和ASMbfp在最低BMI三位数 (T1) 中显著相关.
结论:
- ASMIbmi成为肥胖老年人身体功能和炎症的重要指标,在最高的BMI tertile内.
- ASMbfp显示了所有BMI三角动物与HGS的关联,这表明它在评估肌肉力量方面的相关性.
- 需要在人口层面进一步验证这些发现.
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