泰拉马斯和大脑皮层之间的失调的神经活动介于椎脊髓炎中皮层重组
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Updated: Jul 9, 2025
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A Neuronal Apoptosis Model induced by Spinal Cord Compression in Rat
Published on: June 29, 2021
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Jianchao Chang1, Kun Zhu1, Siya Zhang2
1Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Department of Spine Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Brain research bulletin
|December 3, 2023
概括
在椎脊髓髓病的脊髓压缩改变了大脑的连接和结构. 神经成像生物标志物显示出对患有这种疾病的患者进行分类的潜力.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 椎脊髓炎 (CSM) 涉及脊髓压缩,导致神经缺陷.
- 神经成像研究表明,CSM患者的结构和功能大脑变化,但thalamocortical机制尚不清楚.
研究的目的:
- 为了研究由于CSM中脊髓压缩而导致的thalamocortical功能连接的改变.
- 为了将这些变化与大脑结构和功能重塑相关联.
- 为了确定CSM分类的潜在神经成像生物标志物.
主要方法:
- 休息状态功能性MRI (fMRI) 和结构性MRI在40名CSM患者和34名健康对照中使用.
- 分析包括功能连接 (FC),低频波动的分数振幅 (fALFF),基于表面的形态测量 (SBM) 和独立组件分析 (ICA).
主要成果:
- 脑脊髓炎患者在多个皮质区域的fALFF减少,在感觉运动,前端双脚和视觉网络中的功能连接性发生变化.
- 在insula,前中心/后中心旋转,舌头旋转和骨裂中观察到 sulcus 深度的降低.
- 在CSM患者中发现左丘脑 (VPL) 与右中椎 (MOG) 之间的功能连接性减少.
结论:
- 在CSM中,脊髓压缩会诱导甲状腺皮层连接缺陷,导致皮层结构和功能重组.
- 多模式神经成像分析在CSM患者的分类中实现了86%的准确性,突出了神经成像标记器作为生物标记物的潜力.
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