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Detecting Estrogenic Ligands in Personal Care Products using a Yeast Estrogen Screen Optimized for the Undergraduate Teaching Laboratory
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基于精度的精度测试用于雌激醇测量.

Zhimin Tim Cao1, Robert Rej2, Hubert Vesper3

  • 1Wadsworth Center, New York State Department of Health, Albany, NY, United States; Department of Pathology, SUNY Upstate Medical University, Syracuse, NY, United States.

Clinical biochemistry
|December 3, 2023
PubMed
概括
此摘要是机器生成的。

基于精度的熟练测试 (PT) 对于可靠的雌激素测量至关重要,特别是在低度下. 传统的PT方法可能无法准确地评估非可交换样本的准确性,强调需要改进的评估策略.

关键词:
准确度 准确度 准确度 准确度 准确度雌二醇是雌二醇的一种药物.能力测试 能力测试 能力测试标准化 标准化 标准化

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科学领域:

  • 临床化学 临床化学
  • 实验室医学 实验室医学
  • 内分泌学 在内分泌学.

背景情况:

  • 精确的雌激醇测量对于临床诊断和研究至关重要.
  • 传统的熟练测试 (PT) 可能无法充分评估准确性,特别是在不可交换的样本上.
  • 方法同行群的方法,经常被用作PT的目标,可以掩盖真正的方法准确性.

研究的目的:

  • 用基于准确性的能力测试方法评估雌激醇测量的准确性.
  • 评估各种分析系统和实验室在测量雌激素的性能.
  • 突出传统PT的局限性,并倡导基于准确性的评估.

主要方法:

  • 来自单一捐赠者的5个血清样本分发给76个认证实验室.
  • 实验室分析了雌醇的样本,对CDC定义的目标进行了偏差评估.
  • 使用NYSDOH,CLIA和生物变异 (BV) 的标准来评估性能.

主要成果:

  • 对于常见的分析系统,在低度的雌激醇中观察到显著的积极偏差.
  • 只有很少的分析系统在低度下达到激素标准化计划 (HoSt) 的标准.
  • 虽然大多数实验室都会通过传统的PT,但基于准确性的评估显示了大量的测量变化.

结论:

  • 显然需要提高雌醇测量的准确性,特别是在低度下.
  • 基于精度的PT提供了对方法和分析系统性能更明确的评估.
  • 实施基于精度的PT对于确保可靠的雌激醇测试至关重要.