没有标准可修改风险因素的ST升高心肌梗塞患者的临床结果
Yu Suresvar Singh1, Hideki Wada1, Manabu Ogita1
1Department of Cardiovascular Medicine, Juntendo University Shizuoka Hospital, Izunokuni, Shizuoka, Japan.
Journal of cardiology
|December 3, 2023
概括
没有标准可修改心血管风险因素 (SMuRFs) 的ST段升高心肌梗塞 (STEMI) 患者的长期死亡率更高. 这表明,没有传统风险因素的个体在STEMI后仍然面临着不良预后.
科学领域:
- 心脏病学 心脏病学
- 临床结果研究研究
- 公共卫生 公共卫生
背景情况:
- 标准可修改的心血管风险因素 (SMuRFs) 包括高血压,糖尿病,脂质失调和吸烟.
- 这些因素是冠状动脉疾病的既定风险.
- 缺乏SMuRF的ST段升高心肌梗塞 (STEMI) 患者的预后尚不清楚.
研究的目的:
- 调查SMuRFs缺失与STEMI患者的长期临床结果之间的关联.
- 为了比较STEMI患者的死亡率,有和没有SMuRFs.
主要方法:
- 从1999年至2015年连续接受初级皮肤穿冠状动脉干预 (PCI) 的STEMI患者的回顾性分析.
- 主要终点:长达5年的全因死亡率.
- 用SMuRFs和没有SMuRFs的患者之间的临床特征和结果的比较.
主要成果:
- 在1963年的STEMI患者中,6.4%没有SMuRF;他们年长,瘦,而且更常见的是女性.
- 没有SMuRF的患者在5年内累积死亡率显著增加 (逻辑等级p < 0.0001).
- 没有SMuRF与死亡风险增加独立相关 (HR 1.59,95%CI 1.14-2.21,p=0.006).
结论:
- 没有任何SMuRF的STEMI患者接受初级PCI,与至少有一个SMuRF的患者相比,死亡率更高.
- 没有传统心血管风险因素的个人在STEMI后的预后较差,需要增加临床关注.
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