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多模式实时成像,使用激光光斑对比度和光对比度

Hyun-Seo Park¹, Min-Jae Shim², Yikeun Kim³

¹Industry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, South Korea.

Photodiagnosis and photodynamic therapy

|December 3, 2023

概括

这项研究结合了激光光斑对比成像 (LSCI) 和光成像 (FI) 进行非侵入性,实时的血液 perfusion 可视化. 这种新的系统克服了LSCI的局限性,从而提高了临床诊断能力.

科学领域:

生物医学光学生物医学光学
医疗成像医学成像
生理学生理学生理学

背景情况:

激光斑点对比成像 (LSCI) 提供实时2D perfusion 映射,但在临床环境中面临运动灵敏度和血流分析方面的挑战.
光成像 (FI) 为可视化生物过程提供了补充信息.
近红外 (NIR) 光源提供更深的组织透和减少散射,有利于体内成像.

研究的目的:

开发和验证一个结合LSCI和FI系统的实时,非侵入性输血可视化.
克服LSCI在一般临床应用中的局限性.
使用单个NIR光源用于同时成像模式.

主要方法:

使用785nm NIR光源构建了一个集成LSCI和FI的混合系统.
实验使用流量幻影进行,流量控制 (0-150μl/分钟) 和Intralipid.
在子耳朵模型上进行了体内验证,使用静脉注射不同度的绿色氨酸 (ICG).

主要成果:

综合系统以37-38/秒的速度处理激光光斑图像,从而实现实时分析.
实现了ICG光和LSCI衍生的斑点对比变化的同时可视化.
在子耳朵中成功获得实时对比变化和血 perfusion 的光图像.

结论:

集成的LSCI和FI系统为观察组织 perfusion提供了一个互补的方法.
这种使用单个NIR光源的双模式成像技术,可实现血液输液的非侵入性实时可视化.
开发的系统有望用于增强的临床诊断应用.

关键词:

光成像 (FI) 是指使用光成像.图像处理图像处理印ocyanine绿色 (ICG) 是一种绿色的物质.激光光斑对比成像 (LSCI) 是一种激光光斑对比成像技术.多模式成像技术多模式成像技术接近红外线 (NIR) 的

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