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Updated: Jul 9, 2025

A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3
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由TBK1对基碳化合物受体相互作用蛋白的酸化会负面调节IRF7和I型干扰素反应

Sarah A Kazzaz1, Kashif A Shaikh2, Jesse White2

  • 1Department of Microbiology and Immunology, Penn State College of Medicine, Hershey, Pennsylvania, USA; Medical Scientist Training Program, Penn State College of Medicine, Hershey, Pennsylvania, USA.

The Journal of biological chemistry
|December 3, 2023
PubMed
概括

激酶TBK1在Thr40酸化AIP,控制其与IRF7.7的相互作用. 这种酸化作为一个开关,调节I型干扰素的产生和抗病毒免疫力.

关键词:
坦克结合激酶1 (TBK1) 的作用.抗病毒信号传递的反病毒信号.甲基碳化合物受体相互作用蛋白 (AIP)干扰素调节因子7 (IRF7)这是一种I型干扰子.

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