Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

100
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
100
Assembly of Complex Microtubule Structures01:32

Assembly of Complex Microtubule Structures

1.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
1.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Multiscale characterization of the human claustrum from histology to MRI.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Functional Brain Asymmetry Reveals Heterogeneous Subtypes in Autism Spectrum Disorder.

Autism research : official journal of the International Society for Autism Research·2026
Same author

Sex-related structural alterations across common epilepsies: a worldwide ENIGMA study.

bioRxiv : the preprint server for biology·2026
Same author

Rethinking cortical hypertrophy in temporal lobe epilepsy.

Brain : a journal of neurology·2026
Same author

Brief Report: Child Emotion Dysregulation Mediates the Association Between Parenting Stress and Behavioral Challenges in Autistic Toddlers and Preschoolers.

Journal of autism and developmental disorders·2026
Same author

Use of artificial intelligence in magnetic resonance imaging across the epileptic patient's journey: A meta-analysis of four clinical applications.

Epilepsia·2026
Same journal

Segmentation of the parasagittal dura mater on multi-center 3D-FLAIR MRI.

NeuroImage·2026
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
Same journal

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026
查看所有相关文章

相关实验视频

Updated: Jul 9, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.3K

康涅狄格全方位的结构-功能合模型暗示自闭症中的多突触变化.

Bo-Yong Park1, Oualid Benkarim2, Clara F Weber2

  • 1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Department of Data Science, Inha University, Incheon, South Korea; Department of Statistics and Data Science, Inha University, Incheon, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, South Korea.

NeuroImage
|December 3, 2023
PubMed
概括
此摘要是机器生成的。

自闭症谱系障碍 (ASD) 涉及非典型的大脑网络通信. 这项研究发现,复杂的多突触通路在ASD大脑中模拟的不太准确,特别是在高阶关联区域,将这些差异与症状严重程度联系起来.

关键词:
自闭症 自闭症 自闭症扩散时间是扩散时间.结构功能合 结构功能合突触通信是一种突触通信.

更多相关视频

Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

1.0K
Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice
06:34

Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice

Published on: June 2, 2023

2.8K

相关实验视频

Last Updated: Jul 9, 2025

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

25.3K
Strategies for Assessing Autistic-Like Behaviors in Mice
07:38

Strategies for Assessing Autistic-Like Behaviors in Mice

Published on: September 20, 2024

1.0K
Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice
06:34

Author Spotlight: A Lightweight Drive Implant for Chronic Tetrode Recordings in Juvenile Mice

Published on: June 2, 2023

2.8K

科学领域:

  • 神经科学是一个神经科学.
  • 发育神经科学的发展神经科学.
  • 计算神经科学是一种神经科学.

背景情况:

  • 自闭症谱系障碍 (ASD) 是一种常见的神经发育状况,其特点是大脑结构和功能发生变化.
  • 了解ASD中结构连接和功能大脑活动之间的关系对于阐明其潜在机制至关重要.

研究的目的:

  • 用多式神经成像来研究ASD个体大脑中的结构功能合.
  • 探索单突触和多突触通信通路在ASD相关网络变化的作用.
  • 确定结构-功能合的差异如何与自闭症症状和认知能力有关.

主要方法:

  • 利用自闭症脑成像数据交换 (ABIDE) II数据集的多式磁共振成像数据 (80个ASD,61个对照).
  • 采用里曼的优化程序,从结构连接中预测内在的功能连接,在不同的时间尺度上建模信号传播.
  • 分析了ASD和神经类型对照之间的预测准确度差异 (∆预测准确度),跨越不同大脑区域和网络层次结构.

主要成果:

  • 在两个群体中,在更长的扩散时间尺度上观察到更好的结构-功能预测,突出显示了多突触机制的重要性.
  • 与感官/运动系统相比,ASD和对照组之间的预测准确度差异在跨式联络网络中更为明显.
  • 结构-功能合差异与自闭症症状严重程度,语言和非语言智力的个体变化相关.

结论:

  • 非典型的结构-功能合,特别是涉及多突触通路,是自闭症谱系障碍的关键特征.
  • 网络建模显示,多突触沟通障碍有助于ASD的神经生物学基础.
  • 这些发现提供了关于自闭症症状和认知特征异质性的见解.