康涅狄格全方位的结构-功能合模型暗示自闭症中的多突触变化
Bo-Yong Park1, Oualid Benkarim2, Clara F Weber2
1McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada; Department of Data Science, Inha University, Incheon, South Korea; Department of Statistics and Data Science, Inha University, Incheon, South Korea; Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, South Korea.
NeuroImage
|December 3, 2023
概括
自闭症谱系障碍 (ASD) 涉及非典型的大脑网络通信. 这项研究发现,复杂的多突触通路在ASD大脑中模拟的不太准确,特别是在高阶关联区域,将这些差异与症状严重程度联系起来.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 自闭症谱系障碍 (ASD) 是一种常见的神经发育状况,其特点是大脑结构和功能发生变化.
- 了解ASD中结构连接和功能大脑活动之间的关系对于阐明其潜在机制至关重要.
研究的目的:
- 用多式神经成像来研究ASD个体大脑中的结构功能合.
- 探索单突触和多突触通信通路在ASD相关网络变化的作用.
- 确定结构-功能合的差异如何与自闭症症状和认知能力有关.
主要方法:
- 利用自闭症脑成像数据交换 (ABIDE) II数据集的多式磁共振成像数据 (80个ASD,61个对照).
- 采用里曼的优化程序,从结构连接中预测内在的功能连接,在不同的时间尺度上建模信号传播.
- 分析了ASD和神经类型对照之间的预测准确度差异 (∆预测准确度),跨越不同大脑区域和网络层次结构.
主要成果:
- 在两个群体中,在更长的扩散时间尺度上观察到更好的结构-功能预测,突出显示了多突触机制的重要性.
- 与感官/运动系统相比,ASD和对照组之间的预测准确度差异在跨式联络网络中更为明显.
- 结构-功能合差异与自闭症症状严重程度,语言和非语言智力的个体变化相关.
结论:
- 非典型的结构-功能合,特别是涉及多突触通路,是自闭症谱系障碍的关键特征.
- 网络建模显示,多突触沟通障碍有助于ASD的神经生物学基础.
- 这些发现提供了关于自闭症症状和认知特征异质性的见解.
相关概念视频
01:19Autism Spectrum Disorder
100
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
100
01:32Assembly of Complex Microtubule Structures
1.8K
Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
1.8K