大脑结构网络完整性与患有围产期艾滋病毒的年轻人的情绪症状之间的关系
Gabriella A Caceres1, Kiana A Scambray1, Kathleen Malee2
1Northwestern University Feinberg School of Medicine, Chicago, IL, United States.
Brain, behavior, and immunity
|December 3, 2023
概括
患有围产期获得的艾滋病毒感染 (PHIV) 的年轻人表现出改变的大脑网络,影响情绪调节. 艾滋病毒影响发育中的大脑结构和功能,特别是在突出和默认模式网络中.
科学领域:
- 神经科学是一个神经科学.
- 儿科艾滋病毒研究 儿童艾滋病毒研究
- 脑部成像 脑部成像
背景情况:
- 在全球范围内,围产期获得的艾滋病毒感染 (PHIV) 影响了170万儿童.
- 患有PHIV (YPHIV) 的年轻人表现出更高的情绪和行为症状风险.
- 以前的研究表明,YPHIV中关键的大脑网络 (突出,认知控制,默认模式) 的变化.
研究的目的:
- 研究大脑结构网络完整性与YPHIV情绪症状之间的关系.
- 为了比较YPHIV和未暴露/未感染HIV的青少年之间的大脑网络特征.
- 探索炎症生物标志物与YPHIV中大脑网络完整性的关联.
主要方法:
- 利用磁共振成像 (MRI) 来构建形态相似性网络.
- 应用图形理论来评估网络分离,弹性和集成 (全球效率).
- 在40个YPHIV和214个对照组之间比较了网络指标,并在YPHIV中与情绪症状得分和生物标志物相关联的指标.
主要成果:
- 与对照组相比,YPHIV在突出网络 (SN),默认模式网络 (DMN) 和整个大脑网络中表现出明显较低的全球效率.
- 在DMN和整个大脑网络中,YPHIV显示了网络弹性 (分类性) 的降低.
- 较高的情绪症状得分与SN和DMN的全球效率变化相关;炎症/心脏标志物与网络完整性相关.
结论:
- 艾滋病毒显著影响年轻人的发展大脑网络的结构完整性.
- 与网络效率相关的SN和DMN的功能障碍可能是YPHIV的情绪挑战的基础.
- 这些发现突显了PHIV的神经生物学影响,并提出了潜在的干预目标.
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