吸入式老化微塑料和肺表面活性剂之间的相互作用:潜在的肺部健康风险
Yan Cao1, Qun Zhao1, Fanshu Jiang1
1Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China.
Environmental research
|December 3, 2023
概括
陈旧的微塑料 (MPs) 破坏肺表面活性剂,增加表面张力和减少发泡. 这些老年MP产生自由基,导致氧化损伤,并对呼吸系统健康构成重大风险.
科学领域:
- 环境健康 环境健康
- 材料科学 材料科学 材料科学
- 毒理学 毒理学 毒理学
背景情况:
- 吸入是大气微塑料 (MP) 暴露的主要途径.
- 之前对MP和呼吸系统健康的研究使用了处女塑料,不考虑衰老影响.
- 老年国会议员对呼吸系统的健康影响基本上是未知的.
研究的目的:
- 调查可吸入的老年MP和肺表面活性剂 (LS) 之间的相互作用.
- 在模拟肺液 (SLF) 中探索老年MP诱导的氧化损伤.
- 阐明老年MP在呼吸系统中的毒性背后的机制.
主要方法:
- 在体外实验中分析了老年国会议员与猪LS的界面化学.
- 对暴露于老年MP的SLF中氧化损伤的评估.
- 关于MP聚合和水力动力直径变化的特征.
主要成果:
- 年龄较大的MP显著增加了LS的表面张力,并降低了它的发泡能力.
- 年龄较大的MP表现出更强的LS脂和蛋白质吸附,导致聚合.
- 老年MPs上的持久性自由基诱导了反应性氧物种,导致LS脂质过氧化和蛋白质损伤.
结论:
- 老年MP可以改变肺表面活性剂的功能,可能会损害肺机械.
- 老年国会议员引起的氧化压力对呼吸系统健康构成重大风险.
- 这项研究首次揭示了老年国会议员对人类呼吸系统的毒性影响.
相关概念视频
Breathing
59.3K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
59.3K
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
297
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
297
Inhaled Medications
280
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
280


