化品污染物对胃肠道微生物组的有害影响:神经系统疾病的途径
Neelakanta Sarvashiva Kiran1, Chandrashekar Yashaswini1, Ankita Chatterjee1
1Department of Biotechnology, School of Applied Sciences, REVA University, Kattigenahalli, Yelahanka, Bangalore, Karnataka 560064, India.
Life sciences
|December 3, 2023
概括
化品污染物如 parabens 和 phthalates 可以破坏肠道微生物群,导致胃肠道失调. 这种肠道失衡可能会导致神经毒性,通过肠-大脑轴影响认知功能和发育.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 个人护理产品含有常见的化品污染物,如 parabens,酸盐,硫酸盐,triclosans/triclocarbans以及微型/纳米塑料.
- 这些化学物质是系统分散的,存在于各种体液和组织中,引发了人们对它们广泛影响的担忧.
- 新兴研究将这些化品污染物的暴露与神经毒性影响联系在一起,包括认知衰退和神经发育问题.
研究的目的:
- 审查化品污染物在引起胃肠道失调症中的作用.
- 探索肠道疾病和神经毒性之间的联系.
- 通过肠-大脑轴阐明化品污染物的神经毒性作用背后的机制.
主要方法:
- 对化品污染物,肠道微生物群和神经毒性研究的文献综述.
- 分析将胃肠道失调与神经毒性结果联系起来的机制.
- 综合当前对肠-大脑轴对环境毒素的反应的理解.
主要成果:
- 化品污染物可以诱导胃肠道失调,其特点是肠道微生物群的组成和功能发生变化.
- 肠道功能障碍与肠道透性增加,炎症和代谢功能障碍有关,有助于神经毒性.
- 肠-大脑轴作为一个关键通道,通过该通道,化品污染物诱导的失生症可能会影响神经健康.
结论:
- 胃肠道失调症是暴露于化品污染物的神经毒性影响的重要媒介.
- 了解化品化学品,肠道健康和大脑之间的相互作用对于开发预防和治疗策略至关重要.
- 需要对具体机制进行进一步的研究,以充分解决这些常见环境污染物的复杂毒理学影响.
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