通过分析药房索赔数据,对患有痴呆症的老年人需要特别注意的潜在不适当药物的表征
Yoshihito Kasanami1,2, Takashi Yamamoto1,2, Tomoyoshi Miyamoto1,3
1Faculty of Pharmacy, Kindai University.
Biological & pharmaceutical bulletin
|December 3, 2023
概括
社区药剂师可以帮助减少老年痴呆症患者的潜在不合适药物 (PIMs). 这项研究确定了特定的PIM类别,如抗精神病药物,经常被处方给痴呆症患者,指导抑郁症的努力.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 潜在不合适的药物 (PIMs) 在老年人中很常见,特别是那些患有痴呆症的人.
- 社区药剂师有很好的位置来识别和解决PIM,以改善患者的治疗结果.
研究的目的:
- 描述PIM类别,需要特别注意社区居住的老年痴呆患者.
- 为这个弱势群体制定药剂师主导的减处方策略.
主要方法:
- 分析了来自905家社区药房的333,869名65岁以上患者的匿名药房索赔数据.
- 使用倾向性得分匹配的痴呆症组 (接受痴呆症药物治疗) 和非痴呆症组之间的PIM患病率的比较.
- 后勤回归分析以确定与痴呆症患者显著相关的PIM类别.
主要成果:
- 与非痴呆症患者相比,痴呆症患者接受一个或多种PIM的可能性明显高 (ORs 1.35和1.47).
- 多变量分析显示,在痴呆症患者中",H2阻断剂"",过活膀药物"",抗糖尿病药物"",硫皮"和"抗精神病药物"的处方率显着更高.
- 抗精神病药物在专门针对痴呆症患者的PIM中显示出最高的调整几率比率 (aOR:4.29).
结论:
- 特定的PIM类别,特别是抗精神病药物,不成比例地被处方给老年痴呆症患者.
- 研究结果支持为社区药剂师开发有针对性的干预措施,以促进这些PIM的停止处方.
- 通过减缓处方优化药物管理可以提高痴呆症老年人的护理质量.
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