[心脏amyloidosis和高血压心脏病之间的临床差异]
Ignacio Gallo-Fernández1, José López-Aguilera1, Rafael González-Manzanares1
1Unidad de Insuficiencia Cardiaca, Servicio de Cardiología, Hospital Universitario Reina Sofía, Córdoba, España; Instituto de Investigación Biomédica de Córdoba, IMIBIC, Córdoba, España.
概括
心脏转激素粉症 (TTRA) 和高血压心脏病 (HHD) 的症状是相同的. TTRA患者显示出明显的临床,心电图和回声发现,对起器的需求更高,但死亡率相似.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 电子生理学 电子生理学
背景情况:
- 心脏转氨基粉症 (TTRA) 往往被误诊为高血压心脏病 (HHD) 由于心力衰竭的类似表现与保存的射出分数和心室缩.
- 区分TTRA和HHD对于适当的管理和预后至关重要.
研究的目的:
- 为了确定TTRA和HHD之间的临床,心电图和心声图的差异.
- 分析TTRA和HHD之间的差异预后.
主要方法:
- 在2016-2021年期间对72名接受TTRA查的患者进行了回顾性分析.
- 包括患有高血压心脏病 (HHD) 的患者,接受技术-99m二酸盐光学扫描和自由光链测试.
- 排除患有其他形式的氨基粉症的患者.
主要成果:
- 与HHD患者 (n=39) 相比,TTRA患者 (n=33) 呈现出更高的超敏感性托罗邦素I和NT-proBNP水平.
- 在TTRA中发现了明显的心电图发现 (伪心脏病发作,导电障碍) 和心声图学特征 (过度缩小,功能障碍,填充压力升高).
- 在4年的随访中,TTRA患者对起器的需求更大,但在死亡率,心房动或心力衰竭入院方面没有显著差异.
结论:
- 与高血压心脏病相比,心脏过静氨酸粉症呈现出可识别的临床,心电图和心声学差异.
- 患有TTRA的患者面临需要心脏起器植入的风险增加.
相关概念视频
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
436
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
436
Hypertension and Regulation of Blood Pressure
2.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
2.1K
Pulmonary Hypertension: Classification and Pathogenesis
189
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
189
Antihypertensive Drugs: Action of β1 Blockers
453
β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
453
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
96
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
96


