基因:一个评估.
1Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Progress in biophysics and molecular biology
|December 3, 2023
概括
基因是生物学中定义不好的概念. 现象型,而不是基因,驱动遗传和进化,挑战传统的遗传模型.
科学领域:
- 遗传学 是一个遗传学.
- 进化生物学 进化生物学
- 系统生物学 系统生物学
背景情况:
- 基因是现代生物学中的一个基本概念,但仍然不清楚定义.
- 威廉·约翰森的基因型概念在历史上过度强调了基因的作用.
研究的目的:
- 批判性地分析基因在遗传,进化,发育和形态发生中的作用.
- 为生物基础提出一个替代的框架.
主要方法:
- 对基因概念的历史分析.
- 对证据的批判性审查,包括大肠杆菌长期进化实验 (LTEE).
- 热力学,复杂系统动力学和自我组织原理的应用.
主要成果:
- 证据不支持自发基因突变作为自然选择变异的主要来源.
- 基因不是孟德尔的遗传单位; 约翰森的传递概念在配体表型层面是一个更准确的模型.
- 基因充当被动信息存储器,而表型是主动驱动器.
结论:
- 对基因的传统观点需要重新评估.
- 基于热力学和复杂系统的新生物学框架提供了更准确的视角.
- 现型在遗传,进化,发育和形态发生中起着核心的,积极的作用.
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