优化引力驱动的鼻内滴剂的使用可向骨髓综合体和大鼻输送大量剂量
Amr Seifelnasr1, Farhad Zare2, Xiuhua April Si3
1Department of Biomedical Engineering, University of Massachusetts, 1 University Ave., Falmouth Hall 302I, Lowell, MA, 01854, USA.
Drug delivery and translational research
|December 3, 2023
概括
这项研究开发了一种用于慢性鼻炎治疗的新鼻滴输送方法,显著改善了向骨髓综合体 (OMC) 和大鼻输送的药物输送,变异性较低.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 慢性和过敏鼻炎影响全球12%的人口.
- 目前的治疗方法面临着挑战,原因是鼻鼻无法进入和药物输送效率变化.
- 优化鼻腔药物输送对于有效的鼻炎管理至关重要.
研究的目的:
- 开发和验证一个高效率,低可变性协议,用于将鼻滴输送到骨髓综合体 (OMC) 和大鼻腔.
- 调查输送装置,配方和头方向对药物沉积的影响.
- 为了克服解剖障碍,改善鼻炎治疗.
主要方法:
- 使用患者特定的鼻腔件进行解剖分析和使用光染料可视化液体转位.
- 量化药物输送到OMC和大鼻腔通过滴数和质量使用精确尺度.
- 系统评估交付因素,包括设备类型,配方和头下巴位置 (最佳:头部倾斜40°,[特定下巴倾斜]°).
主要成果:
- 传统的挤压瓶和软雾向OMC显示了低和高度可变的剂量,没有输送到大鼻腔.
- 拟议的方法,使用曲喷嘴和重力驱动的流量,实现了对OMC和大鼻显著的药物输送.
- 建立了最佳的头部和下巴倾斜角度,并量化了有效交付所需的下降数.
结论:
- 开发的鼻滴输送协议通过确保高效率和低可变性,为增强慢性鼻炎治疗提供了一个有希望的解决方案.
- 鼻腔解剖在药物输送方面既有挑战,也有机遇,因此需要进一步研究各种配方和更大的患者队伍.
- 这种方法有可能显著改善患有鼻炎的患者的治疗结果.
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