超超声波刺激有选择性地影响皮质神经血管合跨神经元类型和LFP频段
Zhaocheng Su1,2, Mengyang Liu3, Yi Yuan1,2
1School of Electrical Engineering, Yanshan University, Qinhuangdao 066004, China.
Cerebral cortex (New York, N.Y. : 1991)
|December 3, 2023
概括
超超声刺激 (TUS) 增强神经血管合,特别是在抑制性神经元和特定脑波频率. 这种TUS诱导的合显示了对不同类型的神经元和大脑信号频段的选择性.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 身体生理学 身体生理学
背景情况:
- 之前的研究表明,横超声波刺激 (TUS) 影响皮质神经血管合在低频和高频.
- 对于峰值活动和其他频段 (4-150 Hz) 的TUS的选择性仍然不清楚.
研究的目的:
- 为了研究TUS诱导的皮质神经血管合的选择性.
- 检查TUS对尖峰活动,局部场势和特定频段和神经元类型中的血液动力学的影响.
主要方法:
- 对小鼠的视觉皮层进行了超超声刺激 (TUS).
- 进行了总血红蛋白度,峰值活动和局部场势的同时记录.
- 分析包括皮尔森相关系数和交叉相关性来评估合强度.
主要成果:
- TUS显著增加了神经元发射率 (抑制/刺激) 和血红蛋白度之间的合.
- 抑制性神经元与血红蛋白的合比激发性神经元更强 (相关性高2.1倍).
- 对于马 (30-80 Hz) 和高马 (80-150 Hz) 频段与血红蛋白度观察到增强合.
结论:
- 由TUS诱导的皮层神经血管合表明神经元类型和LFP频段的选择性.
- TUS可以以频率和细胞类型特定的方式调节神经血管合.
- 这些发现有助于更好地了解TUS机制和潜在的治疗应用.
更多相关视频
相关概念视频
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Muscle Stimulation Frequency
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...


