在情绪处理过程中,儿童和青少年双极和单极抑郁症的不同功能模式
Yun Wu1,2,3, Yuan Zhong1,2,3, Gui Zhang1,2,3
1School of Psychology, Nanjing Normal University, 122 Ninghai Road, Gulou District, Nanjing, Jiangsu 210097, China.
Cerebral cortex (New York, N.Y. : 1991)
|December 3, 2023
概括
儿科双极性障碍 (PBD) 和儿科重度抑郁障碍 (p-MDD) 在情绪处理过程中显示出不同的大脑激活模式. PBD影响情绪感知区域,而p-MDD影响情绪评估和调节电路.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 功能性磁共振成像 (fMRI) 研究表明,双相情感障碍 (BD) 和严重抑郁障碍 (MDD) 的成年人情绪处理中的大脑功能障碍.
- 在儿科患者群体中可能存在不同的神经激活模式,需要进一步调查.
研究的目的:
- 在情绪处理过程中调查儿科双相情感障碍 (PBD) 和儿科重度抑郁障碍 (p-MDD) 中常见和明显的脑激活模式.
- 利用元分析方法来综合现有神经成像研究的发现.
主要方法:
- 进行文献搜索以确定相关的fMRI研究.
- 进行了9次元分析,将PBD患者与健康对照 (HC) 和p-MDD患者与HC进行比较.
- 分析了25项涉及252名PBD患者和311名p-MDD患者的25项研究的数据.
主要成果:
- 在消极情绪处理过程中,PBD和p-MDD表现出不同的大脑激活模式.
- 患有PBD的患者在前结,下结,角结和后结皮层的活动变化.
- p-MDD患者在直肠,下额头,轨道额头皮质,胰岛和门中表现出功能障碍.
结论:
- 与PBD相关的脑活动变化主要与情绪感知有关.
- 与p-MDD相关的功能障碍涉及前边缘和奖励相关的电路,这些电路对于情绪评估和调节至关重要.
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