无论行为如何,男性病理在鸟类宿主-病原体系统中驱动传播
Erin L Sauer1, Chloe Connelly1, Weston Perrine1
1Department of Biological Sciences, University of Arkansas, Fayetteville, Arkansas, USA.
The Journal of animal ecology
|December 4, 2023
概括
男性鸟类经历更严重的疾病,导致更高的传播率. 这项研究揭示了基于性别的免疫差异,而不仅仅是行为,在野生动物种群中显著影响流行病的传播.
科学领域:
- 生态生态学 生态生态学
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 主体性别是流行病严重性的关键因素,但将免疫功能与暴露中的行为差异分开是具有挑战性的.
- 由于免疫差异的性别偏差传播,独立于行为,人们对其了解甚少,特别是在非哺乳动物物种中.
研究的目的:
- 为了研究男性偏向病理在驱动性取决于性别的疾病传播在鸟类系统中的作用.
- 确定免疫功能差异是否与行为分开,影响流行病动态.
主要方法:
- 采用了一种取决于性别的多态传播模型.
- 参数化模型与实验暴露的家用金丝雀和传输数据从家.
- 进行了孤立的,基于个体的实验性暴露.
主要成果:
- 与雌性相比,雄性鸟类表现出较短的潜伏期,更长的恢复时间,更高的病原体负载和增加的疾病病理学.
- 模型模拟显示,男性偏见的病理显著增加了流行病的大小,男性比例更高.
- 从全女性模拟到全男性模拟,总流行病规模增加了近10倍.
结论:
- 独立于男性行为的女性偏向抵抗,可以驱动取决于性别的传播动态.
- 基于性别的免疫功能差异在塑造野生动物流行病模式方面发挥着至关重要的作用.
- 结合性别特异性免疫反应的流行病建模对于了解疾病传播至关重要.
关键词:
菌细胞菌菌体 (Mycoplasma gallisepticum) 已经成为一种常见的疾病.鸟类疾病 鸟类疾病疾病传播的疾病传播.病理学的病理学电阻的阻力可以性别偏差感染的感染.性别偏差的传播方式传输模型传输模型传输模型更多相关视频
13:55Sexual Transmission of American Trypanosomes from Males and Females to Naive Mates
Published on: January 27, 2019
15.2K
07:15Preparation of Pseudo-Typed H5 Avian Influenza Viruses with Calcium Phosphate Transfection Method and Measurement of Antibody Neutralizing Activity
Published on: November 22, 2021
2.3K
相关概念视频
Infection
8.0K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
8.0K
Viral Mutations
32.3K
A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
32.3K
Viral Recombination
23.5K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.5K
The Y Chromosome Determines Maleness
6.6K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.6K
Symbiosis
28.2K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
28.2K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
