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盘子中的视网膜生成:从2011年到2022年,视网膜器官的图书法分析和可视化
Wenyue Shen1, An Shao1, Wuyuan Zhou2
1Eye Center, The Second Affiliated Hospital School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, China.
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概括
视网膜器官 (RO) 正在彻底改变视觉研究,其出版物呈现出快速增长. 未来的研究应该集中在特定疾病的模型和治疗遗传性视网膜病变的疗法.
科学领域:
- 干细胞技术 干细胞技术
- 眼科医生 眼科 眼科
- 再生医学是一种再生医学.
背景情况:
- 视网膜器官 (ROs) 是来自干细胞的3D视网膜培养物,模仿器官功能.
- 这项技术代表了干细胞应用的重大进步.
- 视网膜组织为研究视网膜发育和疾病提供了一个有前途的平台.
研究的目的:
- 确定视网膜有机体领域的研究热点和未来方向.
- 了解RO开发和应用中的研究机会的关键领域.
- 分析2011年至2022年RO研究的文献计量数据.
主要方法:
- 从科学网络核心集合 (2011-2022) 中对520篇出版物的图书法分析.
- 使用VOSviewer,CiteSpace和ArcGIS进行数据分析和可视化.
- 确定了出版趋势,领先的机构,多产期刊和关键研究人员.
主要成果:
- 年度出版物增加了40.86%,表明快速增长.
- 美国在出版物 (46.35%) 和引用方面处于领先地位.
- 关键的研究集群包括培养/分化,形态发生,基因疗法和移植.
结论:
- 视网膜有机体研究是一个充满活力和不断扩大的领域.
- 在过去的十年中取得了显著的进展.
- 未来的努力应优先考虑基于RO的模型和治疗视网膜疾病的疗法,特别是遗传视网膜病变.
相关概念视频
01:24Vision
Vision is the result of light being detected and transduced into neural signals by the retina of the eye. This information is then further analyzed and interpreted by the brain. First, light enters the front of the eye and is focused by the cornea and lens onto the retina—a thin sheet of neural tissue lining the back of the eye. Because of refraction through the convex lens of the eye, images are projected onto the retina upside-down and reversed.
01:20Anatomy of the Eyeball
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle layer, the vascular tunic,...