相关实验视频

Updated: Jul 9, 2025

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
10:46

A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer

Published on: September 13, 2022

3.7K

研究阿普塔默的准功能与人类血蛋白之间的关系

Jia Liu1, Zhiqiang Ren1,2, Yang Sun1

  • 1Institute of Molecular Medicine (IMM), Renji Hospital, Shanghai Jiao Tong University School of Medicine, and College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of China.

ACS nano
|December 4, 2023
PubMed
概括

由于血蛋白相互作用,阿普塔默在体内丧失了瘤向能力. 化学修饰,如基化,可以克服这些相互作用,改善aptamer疗效用于临床使用.

关键词:
它们是Aptamers.生物相互作用 生物相互作用生理环境 生理环境血蛋白质是什么 血蛋白质是什么目标化 目标化 目标化

更多相关视频

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins11:34

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

6.7K
Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis08:09

Mapping the Binding Site of an Aptamer on ATP Using MicroScale Thermophoresis

Published on: January 7, 2017

10.7K

相关概念视频

Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
210