溶性纤维对肝功能没有任何好处
Abed Ghavami1, Sepide Talebi2, Hanieh Barghchi3
1Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Iran.
概括
这一元分析发现,可溶性纤维补充剂对健康人群或患有健康状况的人群的肝功能关键生物标志物没有显著影响. 需要进一步进行高质量的研究,以探索特定纤维类型和剂量的潜在益处.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 代谢健康 代谢健康
背景情况:
- 肝功能对整体健康至关重要,可以受到饮食因素的影响.
- 可溶性纤维因其潜在的健康益处而闻名,包括改善新陈代谢.
- 溶性纤维补充剂对肝功能生物标志物的具体影响需要全面评估.
研究的目的:
- 系统地审查和执行随机对照试验 (RCT) 的剂量反应元分析.
- 评估可溶性纤维补充剂对不同人群肝功能参数的影响.
- 为了确定增加可溶性纤维摄入量是否会影响肝酶和蛋白质水平.
主要方法:
- 在PubMed,Scopus和ISI Web of Science的系统文献搜索到2022年4月为期的RCT.
- 包括25个RCT与1744名参与者,分析可溶性纤维的剂量反应关系.
- 肝功能测试中的估计变化,每增加5g/天的可溶性纤维.
主要成果:
- 溶性纤维补充剂并没有显著改变血清中的氨酸转胺酶,酸转胺酶,酸酸酶或玛-氨基转移酶水平.
- 没有观察到对血清胆红素或白蛋白度的显著影响.
- 分析包括了3至52周的干预持续时间和0.0025至40g/天的纤维剂量的研究.
结论:
- 目前的证据不支持可溶性纤维补充剂对肝功能生物标志物的有益影响.
- 长期,高质量的研究是必要的,以调查不同的可溶性纤维类型和剂量的影响.
- 进一步的研究应该优先考虑肝功能作为主要结果,以澄清可溶性纤维的作用.
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