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When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
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使用编辑的MRS进行的谷氨酸酸测量.

Muhammad G Saleh1,2, Andrew Prescot3, Linda Chang4

  • 1Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Magnetic resonance in medicine
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概括

哈达马德编码和梅舍尔-加伍德编辑光谱学 (HERMES) 的重建成功将谷氨酸从谷氨酸中分离出来. 这种先进的磁共振光谱 (MRS) 技术可以同时在体内量化关键的大脑代谢物.

关键词:
对于GABA来说,这是一个很好的选择.赫尔梅斯 (HERMES) 是一个这就是J-差异.谷氨酸酸盐的使用方法葡萄糖氨酸是什么 葡萄糖氨酸

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科学领域:

  • 神经成像是一种神经成像.
  • 磁共振光谱学 (MRS) 是一种技术.
  • 代谢学 代谢学 代谢学

背景情况:

  • 精确量化像谷氨酸这样的大脑代谢物对理解神经功能和疾病至关重要.
  • 使用MRS在体内区分谷氨酸和谷氨胺可能是具有挑战性的,因为光谱重叠.
  • 梅舍尔-加伍德编辑光谱学 (HERMES) 为改进代谢物编辑提供了一个潜在的解决方案.

研究的目的:

  • 在HERMES技术中使用哈达马德编码和重建来证明谷氨酸 (Glu) 的J差异共同编辑.
  • 用HERMES验证使用Glu与谷氨胺 (Gln) 的分离.
  • 评估HERMES在单次扫描中量化Glu,GABA和GSH的体内性能.

主要方法:

  • 密度矩阵模拟和幻影实验进行了HERMES和1D J分辨率光谱的Glu,Gln,GABA和GSH.
  • 赫尔梅斯涉及四个子实验,其中包括特定的编辑脉冲组合.
  • 在体内进行了HERMES和1D J解析的实验,对137名参与者使用3T核磁共振扫描仪进行了测量,并通过LCModel进行了量化.

主要成果:

  • HERMES模拟和幻影数据证实了Glu编辑的信号在2.34 ppm,没有Gln重叠.
  • J 解析的实验显示了 TE 调制,平均信号与 HERMES 编辑的 Glu 信号密切匹配.
  • 在体内定量检测显示,HERMES与Glu的平均1DJ解析方法之间存在很高的相关性 (p < 0.001),变化系数相似.

结论:

  • 正如模拟和幻影研究所证明的那样,HERMES有效地将Glu与Gln分离出来.
  • 在体内,HERMES能够在单个磁共振光谱扫描中同时量化Glu (没有Gln),GABA和GSH.
  • 这种方法为体内神经化学分析提供了一个强大的方法.