颗粒细胞殖民地刺激因子 (Neupogen®;Filgrastim) 在动物模型中加速中性粒细胞恢复硫末诱导的血液毒性
Phillip H Beske1, Jill A Harvilchuck1, Seth T Gibbs2
1Battelle Biomedical Research Center, West Jefferson, Ohio, USA.
Disaster medicine and public health preparedness
|December 4, 2023
概括
在动物模型中,Neupogen® (菲尔格拉斯蒂姆) 在暴露于硫末 (SM) 后加速从中性缺血中恢复. 这项研究表明Neupogen®可能是SM诱导的血液毒性潜在的辅助治疗.
科学领域:
- 毒理学 毒理学 毒理学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 暴露于硫 (SM) 会导致骨髓抑制,损害免疫功能并增加感染风险.
- 对于SM诱导的骨髓抑制,目前还没有经批准的医学治疗方法.
- 血液毒性与SM暴露后患者的不良结果有显著的相关性.
研究的目的:
- 为了评估Neupogen® (filgrastim) 在动物模型中SM诱导的血液毒性的疗效.
- 为了确定Neupogen®是否可以减轻MS对血细胞计数的不良影响.
主要方法:
- 利用动物模型模拟SM诱导的血液毒性.
- 在SM暴露后1天内,Neupogen® (filgrastim) 进行皮下注射.
- 进行了药理动力学/药理动力学分析,以确定Neupogen®的人类等效剂量.
主要成果:
- 在SM暴露后,Neupogen®治疗加速了中性质衰竭的恢复.
- 用Neupogen®治疗的动物表现出更快的体重恢复和临床症状的消失.
- 接受Neupogen®治疗的动物没有表现出与泛细胞衰竭相关的过渡性发烧.
结论:
- 纽波根® (菲尔格拉斯蒂姆) 显示出作为SM诱导的血液毒性的辅助治疗的潜力.
- 动物模型被验证为用于选SM对策的有用工具.
- 这些发现支持先前关于Neupogen®疗效的大型动物研究结果.
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