儿科SARS-CoV-2感染的急性后续病例
Leonard A Jason1, Madeline Johnson1, Chelsea Torres1
1DePaul University.
Fatigue : biomedicine, health & behavior
|December 4, 2023
概括
年轻人的许多SARS-CoV-2感染后急性后续 (PASC) 症状随着时间的推移而改善,但疲劳和劳动后的不适仍然存在. 患有PASC的年轻人通常比患有肌痛性脑筋炎/慢性疲劳综合征 (ME/CFS) 的年轻人体验的症状少.
科学领域:
- 儿科长期COVID研究
- 慢性疲劳综合征研究 慢性疲劳综合征研究
- 传染病的后果 传染病的后果
背景情况:
- SARS-CoV-2 感染的急性后续 (PASC) 影响年轻人,持续的症状影响生活质量.
- 了解PASC症状轨迹对于儿童群体的有效管理和诊断至关重要.
- 与肌痛性脑膜炎/慢性疲劳综合征 (ME/CFS) 的比较有助于区分和描述这些复杂的疾病.
研究的目的:
- 研究被诊断患有PASC的年轻人的持续症状.
- 为了比较患有PASC的年轻人的症状与患有ME/CFS的年轻人的症状.
- 确定症状概况,以量身定制儿科PASC的诊断标准和治疗策略.
主要方法:
- 通过社交媒体招募19名患有PASC儿童的家长填写问卷.
- 在两个时间点评估症状:当前症状和最初感染时的症状.
- 将PASC队列与19名被诊断患有ME/CFS的青少年组成的对照组进行比较.
主要成果:
- 从急性感染到当前报告,在免疫,神经内分泌,疼痛和运动后不适 (PEM) 领域观察到显著的症状减少.
- 在睡眠和PEM领域内,人们注意到持续高水平的疲劳和症状.
- 与PASC患者相比,患有ME/CFS的年轻人表现出更严重的整体症状,特别是在神经认知领域.
结论:
- 虽然年轻人的许多PASC症状随着时间的推移而减弱,但疲劳和PEM症状仍然很重要.
- 调查结果提供了有关儿科PASC的常见症状概况的见解.
- 结果可以为开发更精确的诊断标准和针对PASC青少年的有针对性的治疗干预提供信息.
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