便秘与结直肠癌风险之间的因果关系:双向的双样本孟德尔随机化研究
Long Wu1, Huan Wu2, Fei Huang1
1Department of Anus and Intestinal Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Frontiers in oncology
|December 4, 2023
概括
便秘可能与结直肠癌 (CRC) 有轻微的因果关系,但证据有限. 需要进一步的研究来证实这种关联,并探索其他促成因素.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌 (CRC) 是一个主要的全球健康问题.
- 识别可修改的CRC风险因素对于预防至关重要.
- 便秘已被提议为潜在的CRC风险因素,但很难确定因果关系.
研究的目的:
- 调查便秘和结直肠癌 (CRC) 之间的潜在因果关系.
- 评估便秘是否会增加CRC的风险.
- 检查逆因果关系的可能性,其中CRC可能会影响便秘.
主要方法:
- 进行了一项双样本,双向的门德尔随机化 (MR) 研究.
- 使用全基因组关联研究 (GWAS) 确定了与便秘和CRC相关的遗传变异.
- 这些变异作为工具变量来推断因果关系,在两个方向进行分析.
主要成果:
- 对便秘对CRC影响的分析确定了26种显著单核酸多态 (SNP).
- 反变量加权 (IVW) 方法表明便秘和CRC之间存在潜在的因果关系 (OR = 1.002,P = 0.023),尽管其他MR方法没有确定性.
- 使用各种MR方法,没有发现CRC对便秘的显著因果作用.
结论:
- 这项研究表明,便秘和CRC之间存在潜在的,尽管很弱的因果关系.
- 支持便秘作为CRC的原因的证据有限.
- 建议进行进一步的研究,以探索影响CRC风险的其他因素,并澄清临床影响.
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