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Updated: Jul 9, 2025

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RNA结合蛋白 PTBP1 和 HNRNPL 调节了 CFTR 的 mRNA 衰变

Amna Siddiqui1,2,3, Arpit Saxena1,2, Joshua Echols1,2,4

  • 1Department of Biochemistry and Molecular Genetics and, USA.

Heliyon
|December 4, 2023
PubMed
概括

RNA结合蛋白PTBP1和HNRNPL保护囊性纤维化转膜导电调节器 (CFTR) mRNA免受降解. 这表明PTBP1和HNRNPL是增加CFTRmRNA水平在囊性纤维化患者的潜在治疗点.

关键词:
在CFTR中,CFTR是最重要的.在HNRNPL的基础上,HNRNPL无稽之谈介导的mRNA衰变是没有意义的.在 PTBP1 的基础上.在 mRNA 丰富度上.

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