对T1bN0M0食道癌进行内镜治疗与食道切除术:一种基于人口的研究,使用倾向性得分匹配
Jiamin Zhu1, Xiao Liang1, Shusen Chen2
1Department of Oncology, the Affiliated Jiangyin Hospital of Southeast University Medical College, 163 Shoushan Road, Jiangyin, 214400, China.
Heliyon
|December 4, 2023
概括
内镜治疗和食道切除术为T1bN0M0食道癌 (EC) 提供了比化疗放射治疗的生存优势. 在匹配后,内镜治疗显示了与食道切除术相似的存活率,这表明它是可行的替代方案.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 在瘤学瘤学.
背景情况:
- 食道癌 (EC) 的分期对于治疗选择至关重要.
- 早期EC (T1a) 往往是通过内镜治疗来管理的.
- 对T1b EC进行内镜治疗的疗效需要进一步研究.
研究的目的:
- 为了比较食道切除术,内镜治疗和T1bN0M0 EC的化学放射治疗的疗效.
- 评估不同治疗方式对整体存活率 (OS) 和癌症特定存活率 (CSS) 的影响.
- 为了确定内镜治疗是否是T1bN0M0 EC的食道切除术的可行替代方案.
主要方法:
- 使用了监测,流行病学和最终结果 (SEER) 数据库来识别患者.
- 在治疗组中比较患者人口统计数据:内镜治疗,食道切除术和化疗放射治疗.
- 采用卡普兰-梅尔分析,考克斯回归和倾向性得分匹配 (PSM) 来评估生存结果.
主要成果:
- 确定了820名T1bN0M0 EC患者.
- 内镜治疗和食道切除术显示显著更长的OS和CSS比化疗放射治疗.
- 在PSM之后,食管切除和内镜治疗显示了可比的OS和CSS率.
结论:
- 内镜治疗和食道切除术都为T1bN0M0 EC提供了比化疗放射治疗的生存益处.
- 内镜治疗是T1bN0M0EC的食道切除术的可行替代方案,提供类似的生存结果.
- 对于T1bN0M0 EC的治疗决定,应考虑内镜治疗作为与食道切除术相比较的选择.
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