过去20年心脏新陈代谢的现状和新兴趋势:一项文献计量研究
Hongqin Wang1,2, Xiaolin Liu1,2, Qingbing Zhou1,2
1Institute of Geriatric, Xiyuan Hospital, Beijing, China.
Heliyon
|December 4, 2023
概括
这项图书统计研究分析了心脏代谢研究,强调了心力衰竭和胰岛素抵抗作为关键领域. 新兴趋势侧重于通过代谢操纵改善心肌细胞成熟.
科学领域:
- 心血管研究研究心血管研究
- 代谢科学 代谢科学
- 生物医学文学分析 医学文献分析
背景情况:
- 心脏代谢异常是心血管疾病发展的关键因素.
- 大量的研究工作旨在开发药物来调节心脏新陈代谢.
- 了解心脏代谢研究的动态对于推进心血管医学至关重要.
研究的目的:
- 对有关心脏代谢的科学文献进行全面的文献分析.
- 确定该领域的关键贡献者,有影响力的出版物和新兴研究趋势.
- 为心脏代谢研究的知识动态提供客观的见解.
主要方法:
- 使用Web of Science核心集合 (WoSCC) 数据库进行数据检索.
- 采用了文献计量分析技术来系统地评估文献.
- 分析了出版物数据,作者贡献,机构产出和期刊影响.
主要成果:
- 美国在出版物方面领先 (38.33%),华盛顿大学是领先的机构,而达米安·泰勒 (Damian J. Tyler) 是著名的作者.
- 主要期刊包括美国生理学 - 心脏和循环生理学杂志,分子和细胞心脏病学杂志,心血管研究,循环研究和美国生理学 - 内分泌学和代谢学杂志.
- 主要的关键词和主题包括心力衰竭,胰岛素抵抗,骨肌肉,线粒体,心脏代谢,脂肪酸氧化,葡萄糖代谢和心肌代谢. 关于心力衰竭和体外心血管疾病建模的研究是一个不断增长的热点.
结论:
- 心脏代谢研究正在扩大,重点关注心力衰竭及其与线粒体功能障碍和胰岛素抵抗的联系.
- 一个显著的新兴趋势涉及通过操纵心脏新陈代谢来增强人类诱导的多能干细胞衍生的心肌细胞 (hiPSC-CM) 成熟.
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