导航性支气管镜与计算机断层扫描指导的肺外针活检用于诊断不确定的肺结节:VERITAS多中心随机试验的协议和理由
medRxiv : the preprint server for health sciences
|December 4, 2023
概括
VERITAS试验将电磁导航支气管镜检查与CT指导的胸腔外针活检进行比较,用于诊断肺结节. 这项研究旨在确定导航支气管镜是否与目前的肺结节诊断标准相比不劣.
科学领域:
- 肺部病理学 肺部病理学
- 医疗成像医学成像
- 干预性放射学 干预性放射学
背景情况:
- 肺结节的诊断越来越重要,通常需要活检来区分良性和恶性原因.
- 计算机断层扫描指导的胸针活检 (CT-TTNB) 是标准的,但与较新的导航支气管镜检查缺乏直接比较.
- 由于非比较性数据,这些程序的现有诊断实用性估计可能存在偏差.
研究的目的:
- 为了比较电磁导航支气管镜检查的诊断准确度与外围肺结节的CT-TTNB的数字图解合成.
- 评估导航支气管镜在诊断10-30毫米之间的肺结节时是否与CT-TTNB不逊色.
主要方法:
- VERITAS试验是一项多中心,随机对照研究,将导航支气管镜与CT-TTNB进行比较.
- 参与者被随机分为1:1进行导航支气管镜检查或CT-TTNB检查外围肺结节,试验前恶性瘤的概率至少为10%.
- 主要终点是12个月的诊断准确度;次要终点包括产量,并发症,手术时间和辐射暴露.
主要成果:
- 该研究旨在提供高质量的对肺结节的诊断方式的比较数据.
- 由独立小组进行的集中审查可以最大限度地减少选择偏见.
- 为了确保可靠的估计,用于诊断产量和准确性的保守定义.
结论:
- 这项试验将提供关于肺结节诊断方式的高质量比较数据.
- 结果将为早期肺癌的管理策略提供信息.
- 该研究解决了设计挑战,以确保可靠和公正的研究结果.
相关概念视频
Endoscopic Studies I: Bronchoscopy and Thoracoscopy
210
Endoscopy is a non-surgical medical technique used to examine a person's internal organs and vessels. This lesson will focus on two types of endoscopic studies: bronchoscopy and thoracoscopy.
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
Bronchoscopy
Description
Bronchoscopy is a procedure that involves direct visualization of the larynx, trachea, and bronchi for diagnostic and therapeutic purposes. A flexible fiber optic or rigid bronchoscope is used to carry out the procedure. The fiber-optic bronchoscope is more frequently used due...
210
Radiological Investigation I: X-ray and CT
245
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
245
Radiological Investigation III: Pulmonary Angiogram and PET Scan
95
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
95
Computed Tomography
4.5K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.5K


