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MPRAbase:一个大规模并行记者分析数据库

Jingjing Zhao1,2, Fotis A Baltoumas3, Maxwell A Konnaris4,5

  • 1Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California, USA.

bioRxiv : the preprint server for biology
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概括
此摘要是机器生成的。

大规模并行报告测试 (MPRA) 测量基因调控活性. MPRAbase是一个新的数据库,整合了MPRA实验数据,以便更容易访问和分析.

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科学领域:

  • 基因组学就是基因组学.
  • 分子生物学分子生物学
  • 生物信息学是一种生物信息学.

背景情况:

  • 大规模并行报告员测定 (MPRA) 是评估基因调控元素的高通量技术.
  • 监管机构有多种应用,包括监管要素的发现和变异效应分析.
  • 缺乏集中数据库阻碍了MPRA数据的可访问性和整合.

研究的目的:

  • 开发MPRAbase,MPRA实验结果的手动策划数据库.
  • 为访问和分析MPRA数据提供一个集中的,用户友好的平台.
  • 促进MPRA公布数据在研究界的共享和传播.

主要方法:

  • 出版的MPRA实验的手动策划.
  • 数据编制包括序列,调控活动,细胞类型和生物.
  • 开发一个用于访问和下载数据的Web界面.

主要成果:

  • 目前MPRA数据库包含129个实验,其中有17.718.677个测试元素.
  • 数据涵盖了35种细胞类型和4种生物.
  • 网页界面允许用户下载数据进行独立分析.

结论:

  • 对于研究基因调节的研究人员来说,MPRAbase是一个宝贵的资源.
  • 该数据库促进数据共享,加速MPRA领域的科学发现.
  • MPRAbase通过集中和组织实验结果来提高MPRA数据的实用性.