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Cytotoxic T Cells-mediated Immune Response

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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Updated: Jul 9, 2025

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

一个合成细胞毒性T细胞平台,用于快速原型化TCR功能.

Govinda Sharma¹, James Round¹, Fei Teng¹

¹Michael Smith Genome Sciences Centre; British Columbia Cancer Research Institute; 675 W 10 Ave, Vancouver, BC, V5Z 1L3; Canada.

bioRxiv : the preprint server for biology

|December 4, 2023

概括

研究人员开发了一个新的平台来测试T细胞受体 (TCR) 功能,从而能够精确测量细胞毒性潜力和交叉反应性. 该工具有助于优化治疗TCR,以提高疗效和减少非目标效应.

科学领域:

免疫学免疫学免疫学
细胞生物学细胞生物学
生物技术是生物技术.

关键词:

T细胞受体受体的 T 细胞受体.适应性免疫是一种适应性免疫.生物平台生物平台癌症免疫疗法免疫疗法细胞工程细胞工程高通量选的高通量选合成生物学合成生物学

更多相关视频

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

Published on: July 11, 2016

相关实验视频

Last Updated: Jul 9, 2025

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

Published on: September 10, 2017

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

Published on: October 25, 2016

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

Published on: July 11, 2016

背景情况:

由于模型系统的局限性,对T细胞受体 (TCR) 进行细胞毒性强度和交叉反应性分析具有挑战性.
现有的方法难以在各种HLA等位基因和抗原阵列中测试TCR.

结论:

生物平台允许快速表达和特征的TCR反应.
促进了关于TCR识别模式的新知识生成.
能够优化治疗性TCRs以改善细胞毒性潜力和减少交叉反应性.