脏原始体在更新和分化阶段之间节奏交替,这些阶段与脏分支形态发生同步
Sachin N Davis1,2, Samuel H Grindel1,2, John M Viola1,2
1Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, PA, USA.
bioRxiv : the preprint server for biology
|December 4, 2023
概括
脏发育依赖于脏原始体,平衡更新和分化. 节奏信号通路,如Wnt和Hippo-Yap,调节这种平衡,同步脏形成与脏分支.
科学领域:
- 发展生物学 发展生物学
- 脏生理学 脏生理学
- 干细胞生物学 干细胞生物学
背景情况:
- 哺乳动物脏发育涉及巨大的并行通过脏形成在专门的利基.
- 在这些中,神经元的祖先必须平衡自我更新与分化,以形成新的神经元.
- 与尿道芽分支的结核形成速度同步的机制仍然不清楚.
结论:
- 通过辅助通路的时间调节,如Hippo-Yap和RA,修改了一致的Wnt信号以加快脏形成.
- 这种节奏信号与尿道芽分支的脏形成同步,确保有效的脏发育.
- 这些发现为原始细胞更新/分化平衡提供了时间解决方案,并为合成脏组织生成提供了信息.
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