人类核的深层大脑刺激 accumbens-medial隔膜增强记忆的形成
Svenja Treu1, Juan A Barcia2, Cristina Torres3
1Laboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politécnica de Madrid, Spain.
Research square
|December 4, 2023
概括
核心突 (NAc) 的深脑刺激 (DBS) 增强了情节和空间记忆. 这种新的方法针对调节性大脑输入,为记忆功能障碍治疗提供了一种新的策略.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 认知科学 认知科学
背景情况:
- 记忆功能障碍是一个重大的临床挑战.
- 目前的增强记忆的策略往往针对海马或脑内皮层.
- 核聚集体 (NAc) 通过其在奖励和动机电路中的作用来调节记忆编码.
研究的目的:
- 为了研究核脑深层大脑刺激 (NAc-DBS) 提高记忆功能的功效.
- 为了确定NAc-DBS诱导的记忆增强的最佳电极放置.
- 阐明了NAc-DBS对记忆的影响背后的神经电路.
主要方法:
- 深度大脑刺激 (DBS) 针对精神病患者的内核 (NAc).
- 使用图像识别任务评估情节性记忆 (回忆概率).
- 使用虚拟路径集成任务对空间内存的评估.
- 电极定位分析和结构连接性映射.
- 在老鼠模型中进行体内血液动力学反应分析.
主要成果:
- NAc-DBS显著增加了不常见刺激的回忆概率.
- 在虚拟路径集成空间内存任务中,NAc-DBS提高了性能.
- 最佳的电极放置被确定在后背中背部NAc和中间隔膜.
- 连接性分析突出显示,海马 - 介质膜回路对于记忆编码至关重要.
结论:
- 阶段性NAc电刺激可以动态增强记忆功能.
- 建立了人类NAc在情节性记忆中的关键在线作用.
- 为探索NAc-DBS作为对记忆丧失的治疗干预提供了一个理由.
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