积极选择分析确定了一个WWE域残留物,它将ZAP塑造成一个超级限制因子
Serina Huang1, Juliana Girdner2,3, LeAnn P Nguyen3,4
1Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
bioRxiv : the preprint server for biology
|December 4, 2023
概括
进化分析揭示了指抗病毒蛋白 (ZAP) 中的关键部位,增强其限制病毒复制的能力. 一种特定的ZAP突变通过抑制病毒转化,大大改善了α病毒的阻断.
科学领域:
- * 进化遗传学和病毒学
- *天生的免疫力和宿主-病原体相互作用.
- * 抗病毒防御中的翻译后修改.
背景情况:
- *宿主干扰素通路激活对病毒感染的限制因素.
- *指抗病毒蛋白 (ZAP) 限制各种病毒,但其机制尚不清楚.
- * 之前的研究在灵长类ZAP中发现了有限的积极选择的地点.
结论:
- *第二个WWE域对于工程增强的ZAP抗病毒活动至关重要.
- *调节聚ADP - 核糖) 结合会影响ZAP的限制能力.
- * 结果提供了关于ADP-ribosylation在先天免疫和病毒逃避策略中的作用的见解.
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